Details

Autor(en) / Beteiligte

• Bodilsen, Jacob
• Dalager-Pedersen, Michael
• Schønheyder, Henrik Carl
• Nielsen, Henrik

Titel

Stroke in community-acquired bacterial meningitis: a Danish population-based study

Ist Teil von

• International journal of infectious diseases, 2014-03, Vol.20, p.18-22

Ort / Verlag

Canada: Elsevier Ltd

Erscheinungsjahr

2014

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Summary Objectives Stroke is a serious complication in community-acquired bacterial meningitis (CABM), but the incidence, predispositions, and outcome need further clarification; this pertains in particular to the impact of pre-existing atherosclerosis risk factors. Therefore, we aimed to assess these features in a retrospective population-based cohort study. Methods We included all patients over 16 years of age with CABM in North Denmark Region, 1998–2010. All data were retrieved from the patient records. A Glasgow Outcome Scale score of 1–4 was defined as an unfavourable outcome and 5 as favourable. Results We identified 152 episodes of CABM. In 22 (14%) of the episodes, the patient had a stroke; 15 strokes were ischaemic, three were haemorrhagic, and four were a combination of both. Age and atherosclerosis risk factors were not significantly associated with stroke. However, stroke was associated with a higher in-hospital mortality (27% vs. 16%; age adjusted risk ratio (age aj. RR) 1.43, 95% confidence interval (CI) 0.67–3.04), unfavourable outcome (86% vs. 37%; age adj. RR 2.09, 95% CI 1.59–2.75), and long-term sequelae among survivors (88% vs. 40%, age adj. RR 2.01, 95% CI 1.53–2.65) compared with patients without stroke. Conclusions Stroke is a common complication among adult CABM patients and is associated with long-term sequelae and possibly also death. However, stroke seemed not to be related to atherosclerosis risk factors.