Details

Autor(en) / Beteiligte

• Cifuentes, Liliana, MD
• Vosseler, Sebastian, MSc
• Blank, Simon, PhD
• Seismann, Henning, PhD
• Pennino, Davide, PhD
• Darsow, Ulf, MD
• Bredehorst, Reinhard, MD
• Ring, Johannes, MD
• Mempel, Martin, MD
• Spillner, Edzard, PhD
• Ollert, Markus W., MD

Titel

Identification of Hymenoptera venom–allergic patients with negative specific IgE to venom extract by using recombinant allergens

Ist Teil von

• Journal of allergy and clinical immunology, 2014-03, Vol.133 (3), p.909-910

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2014

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• To the Editor: Epidemiologic studies indicate that 0.05% to 2% of the European and North American population develop systemic reactions after stings from honeybee or yellow jacket species.1 The diagnosis of Hymenoptera venom allergy is based on a combination of a clinical history of anaphylaxis to Hymenoptera sting, positive skin test response, and specific IgE (sIgE) antibodies. Because of the insufficient specificity and sensitivity of intradermal skin testing, ranging, respectively, between 54% and 100% and 26% and 89% depending on extracts and concentrations used, the measurement of sIgE against native extracts of Hymenoptera is an additional but not substitutive in vitro test.2 Thus, the group of patients with a clinical history of anaphylaxis but negative sIgE measurement against commercial venom extracts represents a major diagnostic challenge.