Details

Autor(en) / Beteiligte

• Zhu, Fengcai
• Xu, Wenbo
• Xia, Jielai
• Liang, Zhenglun
• Liu, Yan
• Zhang, Xuefeng
• Tan, Xiaojuan
• Wang, Ling
• Mao, Qunying
• Wu, Junyu
• Hu, Yuemei
• Ji, Tianjiao
• Song, Lifei
• Liang, Qi
• Zhang, Baomin
• Gao, Qiang
• Li, Jingxin
• Wang, Shenyu
• Hu, Yuansheng
• Gu, Shanru
• Zhang, Jianhua
• Yao, Genhong
• Gu, Jianxiang
• Wang, Xushan
• Zhou, Yuchun
• Chen, Changbiao
• Zhang, Minglei
• Cao, Minquan
• Wang, Junzhi
• Wang, Hua
• Wang, Nan

Titel

Efficacy, Safety, and Immunogenicity of an Enterovirus 71 Vaccine in China

Ist Teil von

• The New England journal of medicine, 2014-02, Vol.370 (9), p.818-828

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Enterovirus 71 (EV71) is an important cause of hand, foot, and mouth disease, especially in China. In this phase 3 trial involving 10,077 infants and children in China, an EV71 vaccine provided protection against EV71-associated disease. Enterovirus 71 (EV71), an enterovirus that is not associated with poliomyelitis, was one of the major causative agents of outbreaks of hand, foot, and mouth disease or herpangina in Europe, 1 – 3 Australia, 4 , 5 and Japan 6 , 7 between 1972 and 1988, and it has been implicated in a series of outbreaks across the Asia–Pacific region since the 1990s. 8 – 11 The largest Asia–Pacific epidemic occurred in China in 2008, when approximately 490,000 infections and 126 deaths in infants and young children were reported. 12 The vast majority of severe cases and fatal cases occurred in children younger than 3 years of age. EV71 . . .