Details

Autor(en) / Beteiligte

• Li, Rongcheng
• Liu, Longding
• Mo, Zhaojun
• Wang, Xuanyi
• Xia, Jielai
• Liang, Zhenglun
• Zhang, Ying
• Li, Yanping
• Mao, Qunying
• Wang, Jingjing
• Jiang, Li
• Dong, Chenghong
• Che, Yanchun
• Huang, Teng
• Jiang, Zhiwei
• Xie, Zhongping
• Wang, Lichun
• Liao, Yun
• Liang, Yan
• Nong, Yi
• Liu, Jiansheng
• Zhao, Hongling
• Na, Ruixiong
• Guo, Lei
• Pu, Jing
• Yang, Erxia
• Sun, Le
• Cui, Pingfang
• Shi, Haijing
• Wang, Junzhi
• Li, Qihan

Titel

An Inactivated Enterovirus 71 Vaccine in Healthy Children

Ist Teil von

• The New England journal of medicine, 2014-02, Vol.370 (9), p.829-837

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Enterovirus 71 (EV71), a cause of hand, foot, and mouth disease, may be associated with poliomyelitis-like paralysis. In this report from China, a vaccine was shown to significantly decrease EV71-associated illness in children. Epidemics of hand, foot, and mouth disease in children have emerged recently in Asia and have been caused primarily by enterovirus 71 (EV71) and coxsackievirus A16, 1 which typically show two peak epidemic incidences each year, in May and October. 2 – 5 An important clinical concern regarding hand, foot, and mouth disease is central nervous system injury, which occurs during the disease course in some severe cases and may result in a poor outcome. 6 – 11 Infection with the EV71 C4 genotype accounts for 40.1 to 55.4% of cases of hand, foot, and mouth disease, with considerable associated mortality, including thousands of deaths . . .