Details

Autor(en) / Beteiligte

• Kotsopoulos, Ioannis C
• Papanikolaou, Alexios
• Lambropoulos, Alexandros F
• Papazisis, Konstantinos T
• Tsolakidis, Dimitrios
• Touplikioti, Panagiota
• Tarlatzis, Basil C

Titel

Serous Ovarian Cancer Signaling Pathways

Ist Teil von

• International journal of gynecological cancer, 2014-03, Vol.24 (3), p.410-417

Ort / Verlag

England: by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• ABSTRACTOvarian cancer is the most lethal malignancy of the female genital tract, mainly due to the failure of early diagnosis and the limitations posed by the conventional chemotherapies. Current research has focused in the study of cascades of various cellular molecular reactions, known as signaling pathways. In this review article, authors try to describe the current knowledge regarding the signaling pathways that influence multiple cellular processes in serous ovarian cancer and especially the pathogenesis. Thorough understanding of the precise role of these pathways can lead to the development of new and more effective targeted therapies as well as novel biomarkers in ovarian cancer.