Details

Autor(en) / Beteiligte

• Huang, Yan-You
• Kandel, Denise B.
• Kandel, Eric R.
• Levine, Amir

Titel

Nicotine primes the effect of cocaine on the induction of LTP in the amygdala

Ist Teil von

• Neuropharmacology, 2013-11, Vol.74, p.126-134

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• In human populations, there is a well-defined sequence of involvement in drugs of abuse, in which the use of nicotine or alcohol precedes the use of marijuana, which in turn, precedes the use of cocaine. The term “Gateway Hypothesis” describes this developmental sequence of drug involvement. In prior work, we have developed a mouse model to study the underlying metaplastic behavioral, cellular and molecular mechanisms by which exposure to one drug, namely nicotine, affects the response to another drug, namely cocaine. We found that nicotine enhances significantly the changes in synaptic plasticity in the striatum induced by cocaine (Levine et al., 2011). Here we ask: does the metaplastic effect of nicotine on cocaine also apply in the amygdala, a brain region that is involved in the orchestration of emotions and in drug addiction? We find that pretreatment with nicotine enhances long-term synaptic potentiation (LTP) in response to cocaine in the amygdala. Both short-term (1 day) and long-term (7 days) pre-exposure to nicotine facilitate the induction of LTP by cocaine. The effect of nicotine on LTP is unidirectional; exposure to nicotine following treatment with cocaine is ineffective. This metaplastic effect of nicotine on cocaine is long lasting but reversible. The facilitation of LTP can be obtained for 24 but not 40 days after cessation of nicotine. As is the case in the striatum, pretreatment with Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, simulates the priming effect of nicotine. These results provide further evidence that the priming effect of nicotine may be achieved, at least partially, by the inhibition of histone acetylation and indicate that the amygdala appears to be an important brain structure for the processing of the metaplastic effect of nicotine on cocaine. This article is part of the Special Issue entitled ‘Glutamate Receptor-Dependent Synaptic Plasticity’. •Nicotine pretreatment enhances cocaine induced LTP in the amygdala.•Facilitation of LTP occurs 21d but not after 40d of nicotine cessation.•α7 nAChR agonist mimics the priming effect of nicotine on cocaine.•HDAC inhibition also mimics the priming effect of nicotine on cocaine.•Nicotine via α7 and HDAC inhibition mediates the response to cocaine.