Details

Autor(en) / Beteiligte

• Pievani, Michela
• Bocchetta, Martina
• Boccardi, Marina
• Cavedo, Enrica
• Bonetti, Matteo
• Thompson, Paul M
• Frisoni, Giovanni B

Titel

Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary study

Ist Teil von

• Neurobiology of aging, 2013-07, Vol.34 (7), p.1728-1739

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2013

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Abstract We investigated volume and shape changes in the striatum (caudate, putamen, and nucleus accumbens) of 18 early-onset (EOAD) and 18 late-onset (LOAD) Alzheimer's Disease patients compared with 2 control groups age- and sex-matched to each patient group, and explored the relationship between striatal atrophy and apolipoprotein E ( APOE ) genotype. EOAD patients showed significant shape changes in the left and right ventral putamen ( p < 0.05, corrected for multiple comparison with permutation tests). LOAD patients showed significant reductions in the left and right nucleus accumbens volumes ( p < 0.05; Mann–Whitney test) and shape ( p < 0.05; permutation test). Caudate abnormalities were detected in EOAD and LOAD patients in terms of local enlargements and reductions ( p < 0.05 for the left and right, permutation test). When APOE was considered, significant differences were detected between LOAD ϵ4 carriers and noncarriers in the left and right caudate ( p < 0.05, permutation test). These results suggest distinct patterns of striatal pathology in EOAD and LOAD patients, the dorsal striatum being involved in EOAD and the ventral striatum in LOAD.