Details

Autor(en) / Beteiligte

• Tintori, Cristina
• Laurenzana, Ilaria
• Fallacara, Anna
• Kessler, Ulrich
• Pilger, Beatrice
• Stergiou, Lilli
• Botta, Maurizio

Titel

High-throughput docking for the identification of new influenza A virus polymerase inhibitors targeting the PAaPB1 proteinaprotein interaction

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (1), p.280-282

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A high-throughput molecular docking approach was successfully applied for the selection of potential inhibitors of the Influenza RNA-polymerase which act by targeting the PAaPB1 proteinaprotein interaction. Commercially available compounds were purchased and biologically evaluated in vitro using an ELISA-based assay. As a result, some compounds possessing a 3-cyano-4,6-diphenyl-pyridine nucleus emerged as effective inhibitors with the best ones showing IC50 values in the micromolar range.