Current opinion in biotechnology, 2013-12, Vol.24 (6), p.1129-1136
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Network, nodes and nexus: systems approach to multitarget therapeutics
- Ist Teil von
- Current opinion in biotechnology, 2013-12, Vol.24 (6), p.1129-1136
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Graphical abstract Highlights ► Complex diseases are an outcome of multiple triggers that precipitate into similar phenotypes. ► Systems level understanding can reveal dynamic aspects of disease progression profile. ► Correlation of metabolic remodeling to phenotypic alteration can delineate critical nodes of interventions. ► Multitargeting of key nodes of metabolic networks can be an effective therapeutic strategy. ► Robust and high-throughput data integration in conjunction with simulation would make the drug discovery process more efficient.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0958-1669eISSN: 1879-0429DOI: 10.1016/j.copbio.2013.02.009Titel-ID: cdi_proquest_miscellaneous_1500762708
- Format
- –
- Schlagworte
- Biological, disease course, Disease Progression, diseases, Disorders, Drug Discovery - methods, Dynamical systems, Dynamics, genes, Humans, Internal Medicine, Metabolic Networks and Pathways - drug effects, Molecular Targeted Therapy, Neoplasms - drug therapy, Neoplasms - metabolism, Neoplasms - pathology, Networks, Organisms, Phenotype, phenotypes, Redundancy, spatial variation, Systems Biology - methods, temporal variation, therapeutics, Therapy, tuberculosis, Tuberculosis - drug therapy, Tuberculosis - metabolism, Tuberculosis - pathology