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Novel markers of kidney injury in bipolar patients on long-term lithium treatment
Human psychopharmacology, 2013-11, Vol.28 (6), p.615-618
Rybakowski, Janusz K.
Abramowicz, Maria
Chłopocka-Wozniak, Maria
Czekalski, Stanislaw
2013
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Rybakowski, Janusz K.
Abramowicz, Maria
Chłopocka-Wozniak, Maria
Czekalski, Stanislaw
Titel
Novel markers of kidney injury in bipolar patients on long-term lithium treatment
Ist Teil von
Human psychopharmacology, 2013-11, Vol.28 (6), p.615-618
Ort / Verlag
England: Blackwell Publishing Ltd
Erscheinungsjahr
2013
Quelle
Access via Wiley Online Library
Beschreibungen/Notizen
Objectives We assessed kidney function in long‐term lithium‐treated bipolar patients compared with age‐matched patients not taking lithium, including novel markers of kidney injury such as plasma neutrophil gelatinase‐associated lipocalin (NGAL) and urinary beta‐2 microglobulin (β2‐MG) Methods The study comprised 120 patients with bipolar disorder of which 90 (30 males and 60 females) have been receiving lithium for 5–38 (mean 16) years, and 30 (10 males and 20 females) have never been exposed to lithium. Results Lithium‐treated patients, both men and women, showed significantly higher plasma NGAL and urinary β2‐MG and lower urine specific gravity and estimated glomerular filtration rate (eGFR), compared with patients not taking lithium. In these patients, serum NGAL did not correlate with any clinical feature or other parameter of kidney function. Urinary β2‐MG correlated with serum creatinine and eGFR in the whole group of lithium‐treated patients and in addition, in males, with duration of illness, duration of lithium treatment, and urine specific gravity. Conclusions Lithium treatment causes an impairment of kidney function reflected also by abnormal levels of novel markers of kidney injury. Of these, urinary β2‐MG, as a marker of tubular function seems to be better predictor than serum NGAL in lithium‐treated patients because it shows multiple clinical and biochemical correlations, especially in men. Copyright © 2013 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0885-6222
eISSN: 1099-1077
DOI: 10.1002/hup.2362
Titel-ID: cdi_proquest_miscellaneous_1499138321
Format
–
Schlagworte
Acute-Phase Proteins
,
Adult
,
Aged
,
beta 2-Microglobulin - urine
,
beta-2 microglobulin (β2-MG)
,
Biomarkers - metabolism
,
Bipolar Disorder - drug therapy
,
creatinine
,
Female
,
Glomerular Filtration Rate
,
glomerular filtration rate (GFR)
,
Humans
,
kidney
,
Kidney Diseases - chemically induced
,
Kidney Diseases - physiopathology
,
Kidney Function Tests
,
Lipocalin-2
,
Lipocalins - blood
,
lithium
,
Lithium Compounds - adverse effects
,
Lithium Compounds - therapeutic use
,
Male
,
Middle Aged
,
neutrophil gelatinase-associated lipocalin (NGAL)
,
Proto-Oncogene Proteins - blood
,
Sex Factors
,
Time Factors
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