Details

Autor(en) / Beteiligte

• Grover, Rajesh K.
• Zhu, Xueyong
• Nieusma, Travis
• Jones, Teresa
• Boero, Isabel
• MacLeod, Amanda S.
• Mark, Adam
• Niessen, Sherry
• Kim, Helen J.
• Kong, Leopold
• Assad-Garcia, Nacyra
• Kwon, Keehwan
• Chesi, Marta
• Smider, Vaughn V.
• Salomon, Daniel R.
• Jelinek, Diane F.
• Kyle, Robert A.
• Pyles, Richard B.
• Glass, John I.
• Ward, Andrew B.
• Wilson, Ian A.
• Lerner, Richard A.

Titel

A Structurally Distinct Human Mycoplasma Protein that Generically Blocks Antigen-Antibody Union

Ist Teil von

• Science (American Association for the Advancement of Science), 2014-02, Vol.343 (6171), p.656-661

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• We report the discovery of a broadly reactive antibody-binding protein (Protein M) from human mycoplasma. The crystal structure of the ectodomain of transmembrane Protein M differs from other known protein structures, as does its mechanism of antibody binding. Protein M binds with high affinity to all types of human and nonhuman immunoglobulin G, predominantly through attachment to the conserved portions of the variable region of the κ and λ light chains. Protein M blocks antibody-antigen union, likely because of its large C-terminal domain extending over the antibody-combining site, blocking entry to large antigens. Similar to the other immunoglobulin-binding proteins such as Protein A, Protein M as well as its orthologs in other Mycoplasma species could become invaluable reagents in the antibody field.