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Pharmacovigilance for antiretroviral drugs in Africa: lessons from a study in Abidjan, Cote d'Ivoire
Pharmacoepidemiology and drug safety, 2011-12, Vol.20 (12), p.1303-1310
Jaquet, Antoine
Djima, Mariam Mama
Coffie, Patrick
Kacou, Henri Die
Eholie, Serge P.
Messou, Eugene
Minga, Albert
Guehi, Calixte
Yavo, Jean Claude
Bissagnene, Emmanuel
Dabis, Francois
Ekouevi, Didier K.
2011
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Jaquet, Antoine
Djima, Mariam Mama
Coffie, Patrick
Kacou, Henri Die
Eholie, Serge P.
Messou, Eugene
Minga, Albert
Guehi, Calixte
Yavo, Jean Claude
Bissagnene, Emmanuel
Dabis, Francois
Ekouevi, Didier K.
Titel
Pharmacovigilance for antiretroviral drugs in Africa: lessons from a study in Abidjan, Cote d'Ivoire
Ist Teil von
Pharmacoepidemiology and drug safety, 2011-12, Vol.20 (12), p.1303-1310
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2011
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
ABSTRACT Background Although antiretroviral treatment (ART)–related adverse drug reactions (ADR) are documented in industrialised countries, there is no pre‐existing surveillance system dedicated to ADR monitoring in most African countries. We assessed knowledge towards pharmacovigilance among ART prescribers and available capacity of HIV clinics to conduct ADR monitoring in Abidjan, Côte d'Ivoire. Methods A questionnaire was administered to ART prescribers to assess their knowledge towards the occurrence of ADRs. A retrospective ADR survey was also conducted based on a data query of treatment modification/interruptions in three HIV clinics. Clinical monitors went back to medical charts to review and validate the reasons of the treatment modification/interruptions. Results Of the 81 ART prescribers interviewed, 25 (31%) declared not grading ADRs and 12 (14.8%) declared notifying ADRs to the national regulatory authorities. Among 5252 adult ART‐treated patients who attended the participating clinics in 2008, 599 treatment modifications were identified. Reasons for treatment modification/interruptions identified in the electronic database were documented in the medical charts in 554 cases (92.5%), ADR accounting for 273 cases (45.5%). Toxicity related to ART was graded in only 58 cases (21%) in the medical charts. Discussion This study describes challenges limiting the implementation of reliable pharmacovigilance activities in HIV clinics in Côte d'Ivoire. The lack of knowledge of ART prescribers concerning ADR grading does not support the spontaneous reporting of ADRs. Using treatment modification/interruptions for ADR monitoring appears feasible, but improvements are needed to respond to key questions related to drug toxicities in the context of ART scale‐up in Africa. Copyright © 2011 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 1053-8569, 1099-1557
eISSN: 1099-1557
DOI: 10.1002/pds.2182
Titel-ID: cdi_proquest_miscellaneous_1496896352
Format
–
Schlagworte
Acquired immune deficiency syndrome
,
Adult
,
Adverse Drug Reaction Reporting Systems - statistics & numerical data
,
Anti-HIV Agents - adverse effects
,
Anti-HIV Agents - therapeutic use
,
antiretroviral
,
Cote d'Ivoire
,
Databases, Factual - statistics & numerical data
,
Drug Monitoring
,
Female
,
Health Knowledge, Attitudes, Practice
,
HIV Infections - drug therapy
,
HIV/AIDS
,
Human immunodeficiency virus
,
Humans
,
Male
,
Middle Aged
,
Pharmacovigilance
,
Physicians - standards
,
Physicians - statistics & numerical data
,
Retrospective Studies
,
sub-Saharan Africa
,
Surveys and Questionnaires
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