Details

Autor(en) / Beteiligte

• Santra, Tuhin Subhra
• Wang, Pen-Cheng
• Chang, Hwan-You
• Tseng, Fan-Gang

Titel

Tuning nano electric field to affect restrictive membrane area on localized single cell nano-electroporation

Ist Teil von

• Applied physics letters, 2013-12, Vol.103 (23)

Ort / Verlag

Melville: American Institute of Physics

Erscheinungsjahr

2013

Quelle

American Institute of Physics

Beschreibungen/Notizen

• Interaction of electric field with biological cells is an important phenomenon for field induced drug delivery system. We demonstrate a selective and localized single cell nano-electroporation (LSCNEP) by applying an intense electric field on a submicron region of the single cell membrane, which can effectively allow high efficient molecular delivery but low cell damage. The delivery rate is controlled by adjusting transmembrane potential and manipulating membrane status. Thermal and ionic influences are deteriorated from the cell membrane by dielectric passivation. Either reversible or irreversible by LSCNEP can fully controlled with potential applications in medical diagnostics and biological studies.