European journal of pharmacology, 1987-06, Vol.138 (1), p.141-145
1987
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Details
- Autor(en) / Beteiligte
- Titel
- D-1 dopamine receptor changes after striatal quinolinic acid lesion
- Ist Teil von
- European journal of pharmacology, 1987-06, Vol.138 (1), p.141-145
- Ort / Verlag
- Amsterdam: Elsevier B.V
- Erscheinungsjahr
- 1987
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Regional changes in the distribution of D-1 dopamine receptors produced by unilateral striatal lesions were evaluated in rat brain by quantitative autoradiography. Lesions were induced by local infusion of quinolinic acid, an endogenous excitotoxin that destroys intrinsic neurons, but spares fibers of passage. D-1 receptor density, as determined by [ 125I]SCH 23982 binding, was reduced in caudate-putamen, globus pallidus, substantia nigra, nucleus entopeduncularis on the lesioned side. These results confirm the presence of D-1 receptors on striatal cell bodies and provide direct evidence for the existence of presynaptic D-1 receptors on the terminals of striatal projections.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-2999eISSN: 1879-0712DOI: 10.1016/0014-2999(87)90351-7Titel-ID: cdi_proquest_miscellaneous_14942672
- Format
- –
- Schlagworte
- [ 125I]SCH 23982, Animals, Anticonvulsants - toxicity, Autoradiography, Benzazepines - analogs & derivatives, Benzazepines - pharmacology, Biological and medical sciences, Brain Chemistry - drug effects, Central nervous system, Central neurotransmission. Neuromudulation. Pathways and receptors, Corpus Striatum - metabolism, D-1 dopamine receptors, Dopamine Antagonists, dopamine D1, Dopamine receptor interactions, Fundamental and applied biological sciences. Psychology, Male, neostriatum, Pyridines - toxicity, Quinolinic Acid, Quinolinic Acids - toxicity, Rats, Rats, Inbred Strains, Receptors, Dopamine - metabolism, Receptors, Dopamine D1, Striatal lesion, Vertebrates: nervous system and sense organs