Details

Autor(en) / Beteiligte

• IRACE, Concetta
• CARALLO, Claudio
• SCAVELLI, Faustina
• DE FRANCESCHI, Maria Serena
• ESPOSITO, Teresa
• GNASSO, Agostino

Titel

Blood Viscosity in Subjects With Normoglycemia and Prediabetes

Ist Teil von

• Diabetes care, 2014-02, Vol.37 (2), p.488-492

Ort / Verlag

Alexandria, VA: American Diabetes Association

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Blood viscosity (BV) is higher in diabetic patients and might represent a risk factor for the development of insulin resistance and type 2 diabetes. However, data in subjects with normal glucose or prediabetes are missing. In the current study, we evaluated the relationship between BV and blood glucose in subjects with normal glucose or prediabetes. Enrolled subjects were divided into three groups according to blood glucose: group A (n = 74), blood glucose <90 mg/dL; group B (n = 96), blood glucose ranging from 90 to 99 mg/dL; and group C (n = 94), blood glucose ranging from 100 to 125 mg/dL. BV was measured at 37°C with a cone-plate viscometer at shear rates ranging from 225 to 22.5 s(-1). Blood pressure, blood lipids, fibrinogen, and plasma viscosity were similar in the three groups. BMI and waist circumference were significantly increased in group C. Hematocrit (P < 0.05) and BV (P between 0.01 and 0.001) were significantly higher in groups B and C compared with group A. Blood glucose was significantly and inversely correlated with HDL cholesterol and directly with BMI, waist, hematocrit (r = 0.134), and BV (from 225 s(-1) to 22.5 s(-1); r ranging from 0.162 to 0.131). BV at shear rate 225 s(-1) was independently associated with blood glucose. The current study shows a direct relationship between BV and blood glucose in nondiabetic subjects. It also suggests that, even within glucose values considered completely normal, individuals with higher blood glucose levels have increased BV comparable with that observed in subjects with prediabetes.