Details

Autor(en) / Beteiligte

• Biscione, Fernando Martín
• Westin, Mateus Rodrigues
• Ribeiro, Karina Mota
• Estevam, Denize Lotufo
• Cardoso, Sandra Wagner
• Tenore, Simone Barros
• Neto, Lauro Ferreira da Silva Pinto
• Alencastro, Paulo Ricardo
• Suffert, Theodoro Armando
• de Moraes, Mônica Jacques
• Barbosa, Alexandre Naime
• Morejón, Karen Mirna Loro
• de Arruda, Érico Antônio Gomes
• Silveira, Jussara María
• Neto, José Luiz Andrade
• Greco, Dirceu Bartolomeu
• Tupinambás, Unaí

Titel

Virologic and Immunologic Effectiveness at 48 Weeks of Darunavir–Ritonavir-Based Regimens in Treatment-Experienced Persons Living with HIV-1 Infection in Clinical Practice: A Multicenter Brazilian Cohort

Ist Teil von

• Journal of the International Association of Providers of AIDS Care, 2014-01, Vol.13 (1), p.63-68

Ort / Verlag

Los Angeles, CA: SAGE Publications

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Introduction: Published data addressing the effectiveness of darunavir–ritonavir (DRV/r)-based therapy for multiexperienced patients in developing countries are scarce. This study evaluated the 48-week virologic and immunologic effectiveness of salvage therapy based on DRV/r for the treatment of multidrug-experienced HIV-1-infected adults in Brazil. Materials and Methods: A multicenter retrospective cohort study was carried out with multidrug-experienced adults who were on a failing antiretroviral therapy and started a DRV/r-based salvage therapy between 2008 and 2010. The primary effectiveness end point was the proportion of patients with virologic success (plasma HIV-1 RNA <50 copies/mL at week 48). Results: At 48 weeks, 73% of the patients had HIV-RNA <50 copies/mL and a mean increase of 108 CD4 cells/mm3. Higher baseline viral load, lower baseline CD4 count, younger age, and 3 or more DRV/r-associated resistance mutations were significantly predictive of virologic failure. Concomitant use of raltegravir was strongly associated with virologic success. Conclusion: The use of DRV/r-based regimens for salvage therapy is an effective strategy in the clinical care setting of a developing country.