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Nomograms for preoperative prediction of prognosis in patients with oral cavity squamous cell carcinoma
Cancer, 2014-01, Vol.120 (2), p.214-221
Montero, Pablo H.
Yu, Changhong
Palmer, Frank L.
Patel, Purvi D.
Ganly, Ian
Shah, Jatin P.
Shaha, Ashok R.
Boyle, Jay O.
Kraus, Dennis H.
Singh, Bhuvanesh
Wong, Richard J.
Morris, Luc G.
Kattan, Michael W.
Patel, Snehal G.
2014
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Montero, Pablo H.
Yu, Changhong
Palmer, Frank L.
Patel, Purvi D.
Ganly, Ian
Shah, Jatin P.
Shaha, Ashok R.
Boyle, Jay O.
Kraus, Dennis H.
Singh, Bhuvanesh
Wong, Richard J.
Morris, Luc G.
Kattan, Michael W.
Patel, Snehal G.
Titel
Nomograms for preoperative prediction of prognosis in patients with oral cavity squamous cell carcinoma
Ist Teil von
Cancer, 2014-01, Vol.120 (2), p.214-221
Ort / Verlag
Hoboken, NJ: Wiley-Blackwell
Erscheinungsjahr
2014
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND This study sought to develop prognostic tools that will accurately predict overall and cancer‐related mortality and risk of recurrence in individual patients with oral cancer based on host and tumor characteristics. These tools would take into account numerous prognosticators beyond those covered by the traditional TNM (tumor–node–metastasis) staging system. METHODS Demographic, host, and tumor characteristics of 1617 patients with cancer of the oral cavity, who were treated primarily with surgery at a single‐institution tertiary care cancer center between 1985 and 2009, were reviewed from a preexisting database. Recurrent disease was recorded in 509 patients (456 locoregional and 116 distant); 328 patients died of cancer‐related causes, and 542 died of other causes. The median follow‐up was 42 months (range, 1‐300 months). The following variables were analyzed as predictors of prognosis: age, sex, race, alcohol and tobacco use, oral cavity subsite, invasion of other structures, comorbidity, tumor size, and clinical nodal status. The stepdown method was used to select the statistically most influential predictors for inclusion in the final nomogram for each outcome of interest. RESULTS The most influential predictors of both recurrence and cancer‐specific mortality probability (CSMP) were tumor size, nodal status, subsite, and bone invasion. Nomograms were generated for prediction of overall survival (OS), CSMP, and locoregional recurrence‐free probability (LRRFP). The nomograms were internally validated with an overfit‐corrected predictive discrimination metric (concordance index) for OS of 67%, CSMP of 66%, and LRRFP of 60%. CONCLUSIONS Nomograms have been developed that can reasonably estimate OS, CSMP, and LRRFP based on specific tumor and host characteristics in patients with oral cancer. Cancer 2014;120:214–221. © 2013 American Cancer Society. This study represents the first attempt at using individualized outcome prediction in head and neck oncology based on a large cohort of uniformly treated patients with oral cavity cancer. Nomograms have been developed that can reasonably estimate overall survival, cancer‐specific mortality probability, and locoregional recurrence‐free probability based on specific tumor and host characteristics in patients with oral cancer.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.28407
Titel-ID: cdi_proquest_miscellaneous_1492644726
Format
–
Schlagworte
Aged
,
Biological and medical sciences
,
Bone Neoplasms - mortality
,
Bone Neoplasms - secondary
,
Carcinoma, Squamous Cell - mortality
,
Carcinoma, Squamous Cell - pathology
,
Carcinoma, Squamous Cell - surgery
,
Female
,
Follow-Up Studies
,
head and neck cancer
,
Humans
,
Male
,
Medical sciences
,
Middle Aged
,
Mouth Neoplasms - surgery
,
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
,
Neoplasm Recurrence, Local
,
nomogram
,
Nomograms
,
oral cancer
,
oral cavity cancer
,
Otorhinolaryngology. Stomatology
,
outcome prognosis
,
predictive tools
,
Preoperative Period
,
Prognosis
,
Proportional Hazards Models
,
recurrence prognosis
,
Reproducibility of Results
,
survival prognosis
,
Tumors
,
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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