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In the eye of the storm: mitochondrial damage during heart and brain ischaemia
Ist Teil von
The FEBS journal, 2013-10, Vol.280 (20), p.4999-5014
Ort / Verlag
England: Blackwell Publishing Ltd
Erscheinungsjahr
2013
Link zum Volltext
Quelle
Wiley(RISS)
Beschreibungen/Notizen
We review research investigating mitochondrial damage during heart and brain ischaemia, focusing on the mechanisms and consequences of ischaemia‐induced and/or reperfusion‐induced: (a) inhibition of mitochondrial respiratory complex I; (b) release of cytochrome c from mitochondria; (c) changes to mitochondrial phospholipids; and (d) nitric oxide inhibition of mitochondria. Heart ischaemia causes inhibition of cytochrome oxidase and complex I, release of cytochrome c, and induction of permeability transition and hydrolysis and oxidation of mitochondrial phospholipids, but some of the mechanisms are unclear. Brain ischaemia causes inhibition of complexes I and IV, but other effects are less clear.
Mitochondria are at the center of ischaemic damage to heart and brain. Here, we highlight the mechanisms and consequences of early events in mitochondrial ischaemic damage, particularly complex I inhibition and the release of cytochrome c from mitochondria, and discuss how inhibition of mitochondria by nitric oxide may contribute to ischaemic injury to heart and brain.