Details

Autor(en) / Beteiligte

• Park, Kyoung Sook, MD
• Han, Seung Hyeok, MD, PhD
• Kie, Jeong Hae, MD
• Nam, Ki Heon, MD
• Lee, Mi Jung, MD
• Lim, Beom Jin, MD, PhD
• Kwon, Young Eun, MD
• Kim, Yung Ly, MD
• An, Seong Yeong, MD
• Kim, Chan Ho, MD
• Doh, Fa Mee, MD
• Koo, Hyang Mo, MD
• Oh, Hyung Jung, MD
• Kang, Shin-Wook, MD, PhD
• Choi, Kyu Hun, MD, PhD
• Jeong, Hyeon Joo, MD, PhD
• Yoo, Tae-Hyun, MD, PhD

Titel

Comparison of the Haas and the Oxford classifications for prediction of renal outcome in patients with IgA nephropathy

Ist Teil von

• Human pathology, 2014-02, Vol.45 (2), p.236-243

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Pathologic features can provide valuable information for determining prognosis in IgA nephropathy (IgAN). However, it is uncertain whether the Oxford classification, a new classification of IgAN, can predict renal outcome better than previous ones. We conducted a retrospective cohort study in 500 patients with biopsy-proven IgAN between January 2002 and December 2010 to compare the ability of the Haas and the Oxford classifications to predict renal outcome. Primary outcome was a doubling of the baseline serum creatinine concentration (D-SCr). During a mean follow-up of 68 months, 52 (10.4%) and 35 (7.0%) developed D-SCr and end-stage renal disease, respectively. There were graded increases in the development of D-SCr in the higher Haas classes. In addition, the primary endpoint of D-SCr occurred more in patients with the Oxford M and T lesions than those without such lesions. In multivariate Cox regression analyses, the Haas class V (HR, 12.19; P = .002) and the Oxford T1 (hazard ratio [HR], 6.68; P < .001) and T2 (HR, 12.16; P < .001) lesions were independently associated with an increased risk of reaching D-SCr. Harrell’s C index of each multivariate model with the Haas and the Oxford classification was 0.867 ( P = .015) and 0.881 ( P = .004), respectively. This was significantly higher than that of model with clinical factors only ( C = 0.819). However, there was no difference in C -statistics between the 2 models with the Haas and the Oxford classifications ( P = .348). This study suggests that the Haas and the Oxford classifications are comparable in predicting progression of IgAN.