Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (1), p.280-282
2014
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Details
- Autor(en) / Beteiligte
- Titel
- High-throughput docking for the identification of new influenza A virus polymerase inhibitors targeting the PA-PB1 protein-protein interaction
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (1), p.280-282
- Ort / Verlag
- England
- Erscheinungsjahr
- 2014
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- A high-throughput molecular docking approach was successfully applied for the selection of potential inhibitors of the Influenza RNA-polymerase which act by targeting the PA-PB1 protein-protein interaction. Commercially available compounds were purchased and biologically evaluated in vitro using an ELISA-based assay. As a result, some compounds possessing a 3-cyano-4,6-diphenyl-pyridine nucleus emerged as effective inhibitors with the best ones showing IC50 values in the micromolar range.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2013.11.019Titel-ID: cdi_proquest_miscellaneous_1490784180
- Format
- –
- Schlagworte
- Dose-Response Relationship, Drug, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - pharmacology, High-Throughput Screening Assays, Influenza A virus - enzymology, Models, Molecular, Molecular Structure, Protein Binding - drug effects, Pyridines - chemistry, Pyridines - pharmacology, RNA Replicase - antagonists & inhibitors, RNA Replicase - metabolism, Structure-Activity Relationship, Viral Proteins - antagonists & inhibitors, Viral Proteins - metabolism