Details

Autor(en) / Beteiligte

• Fagioli, Franca
• Quarello, Paola
• Pollichieni, Simona
• Lamparelli, Teresa
• Berger, Massimo
• Benedetti, Fabio
• Barat, Veronica
• Marciano, Renato
• Rambaldi, Alessandro
• Bacigalupo, Andrea
• Sacchi, Nicoletta

Titel

Quality of harvest and role of cell dose in unrelated bone marrow transplantation: An Italian Bone Marrow Donor Registry-Gruppo Italiano Trapianto di Midollo Osseo Study

Ist Teil von

• Hematology (Luxembourg), 2014-01, Vol.19 (1), p.1-9

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• In this study, we investigated the factors affecting cell dose harvest and the role of cell dose on outcome. We analysed data from a cohort of 703 patients who underwent unrelated bone marrow transplantation facilitated by IBMDR in GITMO centers between 2002 and 2008. The median-infused cell doses is 3.7 × 10 8 /kg, the correlation between the nucleated cells requested from transplant centers and those harvested by collection centers was adequate. A harvested/requested cells ratio lower than 0.5 was observed only in 3% of harvests. A volume of harvested marrow higher than the median value of 1270 ml was related to a significant lower infused cell dose (χ 2 : 44.4; P < 0.001). No patient- or donor-related variables significantly influenced the cell dose except for the recipient younger age (χ 2 : 95.7; P < 0.001) and non-malignant diseases (χ 2 : 33.8; P < 0.001). The cell dose resulted an independent predictor factor for a better outcome in patients affected by non-malignant disease (P = 0.05) while early disease malignant patients receiving a lower cell dose showed a higher risk of relapse (P = 0.05).