Details

Autor(en) / Beteiligte

• Park, Ji Hoon
• Baek, Eun Kyung
• Choi, Chang Hwan
• Lee, Kyung Hun
• Kim, Beom Jin
• Kim, Jeong Wook
• Kim, Jae Gyu
• Chang, Sae Kyung

Titel

Comparison of the efficacy of 4- and 8-week lansoprazole treatment for ESD-induced gastric ulcers: a randomized, prospective, controlled study

Ist Teil von

• Surgical endoscopy, 2014, Vol.28 (1), p.235-241

Ort / Verlag

Boston: Springer US

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Although endoscopic submucosal dissection (ESD) is widely used to treat gastric neoplasms, there is no consensus for the optimal treatment for ESD-induced ulcers. We compared efficacy between 4 and 8 weeks of lansoprazole treatment for iatrogenic gastric ulcers that developed after ESD. Methods Eighty-four patients who were diagnosed with gastric adenoma or early gastric cancer were enrolled and randomly assigned to treatment with lansoprazole (30 mg/day) for 4 or 8 weeks. Eight weeks after ESD, we conducted follow-up endoscopy to compare ulcer stage and ulcer reduction ratio (dividing the ulcer dimension at 8 weeks by the initial ulcer dimension) between the two groups. Results From the 84 patients, 69 patients were included in the final analysis, with 34 in the 4-week group and 35 in the 8-week group. Eight weeks after ESD, there were no significant difference observed between the two groups in terms of the ulcer stage (68 % in the scar stage in the 4-week group vs. 69 % in the 8-week group, P  = 0.93) or the ulcer reduction ratio (0.0081 ± 0.015 in the 4-week group vs. 0.0037 ± 0.008 in the 8-week group, P  = 0.15). Also, in the subgroup analysis among the patients with large ulcers (>30 mm), those parameters were not different. Conclusions For ESD-induced gastric ulcers, treatment with lansoprazole for 4 weeks was as effective as treatment for 8 weeks. Considering cost-effectiveness, proton pump inhibitor therapy for 4 weeks may be sufficient for ESD-induced gastric ulcers.