Details

Autor(en) / Beteiligte

• Wreggett, KA

Titel

Alkylation of the bovine anterior pituitary D sub(2)-dopamine receptor: Inconsistency with predictions of the ternary complex model

Ist Teil von

• Biochemical and biophysical research communications, 1987-01, Vol.147 (3), p.1070-1076

Erscheinungsjahr

1987

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The ability of a high affinity, N-chloroethyl derivative to irreversibly occupy dopamine receptors has been used to probe the nature of the interaction of the bovine anterior pituitary D sub(2)-dopamine receptor with a putative G-protein. The data were not consistent with the predictions of the ternary complex model. The results indicate that the receptor and the G-protein might be considered as a complex where ligand binding to either component regulates ligand interactions of the other, rather than enhancing the degree of association of the components.