Details

Autor(en) / Beteiligte

• Yang, Issac Y.
• Cui, Yifan
• Wiens, Curtis N.
• Wade, Trevor P.
• Friesen-Waldner, Lanette J.
• McKenzie, Charles A.

Titel

Fat fraction bias correction using T1 estimates and flip angle mapping

Ist Teil von

• Journal of magnetic resonance imaging, 2014-01, Vol.39 (1), p.217-223

Ort / Verlag

United States: Blackwell Publishing Ltd

Erscheinungsjahr

2014

Quelle

Access via Wiley Online Library

Beschreibungen/Notizen

• Purpose To develop a new method of reducing T1 bias in proton density fat fraction (PDFF) measured with iterative decomposition of water and fat with echo asymmetry and least‐squares estimation (IDEAL). Materials and Methods PDFF maps reconstructed from high flip angle IDEAL measurements were simulated and acquired from phantoms and volunteer L4 vertebrae. T1 bias was corrected using a priori T1 values for water and fat, both with and without flip angle correction. Signal‐to‐noise ratio (SNR) maps were used to measure precision of the reconstructed PDFF maps. PDFF measurements acquired using small flip angles were then compared to both sets of corrected large flip angle measurements for accuracy and precision. Results Simulations show similar results in PDFF error between small flip angle measurements and corrected large flip angle measurements as long as T1 estimates were within one standard deviation from the true value. Compared to low flip angle measurements, phantom and in vivo measurements demonstrate better precision and accuracy in PDFF measurements if images were acquired at a high flip angle, with T1 bias corrected using T1 estimates and flip angle mapping. Conclusion T1 bias correction of large flip angle acquisitions using estimated T1 values with flip angle mapping yields fat fraction measurements of similar accuracy and superior precision compared to low flip angle acquisitions. J. Magn. Reson. Imaging 2014;39:217–223. © 2013 Wiley Periodicals, Inc.