International journal of pharmaceutics, 2011-10, Vol.419 (1), p.308-313
2011
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- Autor(en) / Beteiligte
- Titel
- Cell penetrating peptide-mediated systemic siRNA delivery to the liver
- Ist Teil von
- International journal of pharmaceutics, 2011-10, Vol.419 (1), p.308-313
- Ort / Verlag
- Amsterdam: Elsevier B.V
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The cell-penetrating peptide (CPP) is one of the most attractive tools for efficiently delivering biomolecules to a target organelle. Here, we describe the use of octaarginine (R8)-modified lipid nanoparticles for the efficient and targeted in vivo delivery of siRNA to the liver. In this study, SR-BI (a scavenger receptor class B, member 1) was targeted by this nanoparticle. Our results demonstrate that R8-modified lipid nanoparticles can be used for the efficient and targeted delivery of liver siRNA to induce the specific knock-down of an endogenous gene with minimum liver toxicity and immune response, and that this CPP based technology holds considerable promise for further in vivo biological applications of siRNA.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0378-5173eISSN: 1873-3476DOI: 10.1016/j.ijpharm.2011.07.038Titel-ID: cdi_proquest_miscellaneous_1468365205
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, CD36 Antigens - genetics, Cell penetrating peptide, Cell-Penetrating Peptides - chemistry, Female, Gene Knockdown Techniques, Gene Transfer Techniques, General pharmacology, genes, hepatotoxicity, Immune response, Lipids - chemistry, Liver, Liver - metabolism, Male, Medical sciences, Mice, Mice, Inbred C57BL, Mice, Inbred ICR, Nanoparticles, Octaarginine, Oligopeptides - chemistry, Pharmaceutical technology. Pharmaceutical industry, Pharmacology. Drug treatments, RNA, Small Interfering - administration & dosage, RNA, Small Interfering - toxicity, siRNA delivery, small interfering RNA