Details

Autor(en) / Beteiligte

• Capon, Francesca

Titel

IL36RN Mutations in Generalized Pustular Psoriasis: Just the Tip of the Iceberg?

Ist Teil von

• Journal of investigative dermatology, 2013-11, Vol.133 (11), p.2503-2504

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2013

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• As IL36RN mutations are a cause of generalized pustular psoriasis (GPP), three recent investigations attempted to correlate the IL36RN genotype with GPP clinical presentations. These studies found that IL36RN mutations account for only a fraction of GPP cases presenting with concomitant psoriasis vulgaris (PV; common or typical psoriasis). Pathogenic alleles were also found in control populations, indicating that environmental triggers and/or modifier genes may contribute to the disease.