Details

Autor(en) / Beteiligte

• Kicha, Alla A.
• Kalinovsky, Anatoly I.
• Antonov, Alexander S.
• Radchenko, Oleg S.
• Ivanchina, Natalia V.
• Malyarenko, Timofey V.
• Savchenko, Alexander M.
• Stonik, Valentin A.

Titel

Determination of C-23 Configuration in (20R)-23-Hydroxycholestane Side Chain of Steroid Compounds by 1H and 13C NMR Spectroscopy

Ist Teil von

• Natural product communications, 2013-09, Vol.8 (9), p.1219-1222

Ort / Verlag

Los Angeles, CA: SAGE Publications

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Epimeric (20R,23R)- and (20R,23S)-23-hydroxycholestane steroids were synthesized. Their structures were elucidated by extensive 1H and 13C NMR spectroscopy and application of the Mosher's method. All proton and carbon signals of the side chains were assigned. Based on these assignments spectral data allow the determination of the C-23 stereochemistry of (20R)-23-hydroxycholestane side chains of the new natural steroids by comparison with spectra of the obtained model compounds. As a result, the C-23 configuration of two steroid compounds from the starfishes Lethasterias nanimensis chelifera and Lethasterias fusca was established.