Details

Autor(en) / Beteiligte

• Rescignano, N.
• Fortunati, E.
• Montesano, S.
• Emiliani, C.
• Kenny, J.M.
• Martino, S.
• Armentano, I.

Titel

PVA bio-nanocomposites: A new take-off using cellulose nanocrystals and PLGA nanoparticles

Ist Teil von

• Carbohydrate polymers, 2014, Vol.99, p.47-58

Ort / Verlag

Kidlington: Elsevier Ltd

Erscheinungsjahr

2014

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• •Cellulose nanocrystals (CNC) and PLGA nanoparticles (NPs) were synthesized.•Ternary poly(vinyl alcohol) (PVA) nanocomposites with CNC and PLGA NPs were produced.•CNC are able to increase the PVA elongation properties.•The synergic presence of CNC and PLGA produced a nucleation effect.•Stem cells up-take easily the NPs released from PVA bio-nanocomposites. The formation of a new generation of hybrid bio-nanocomposites is reported: these are intended at modulating the mechanical, thermal and biocompatibility properties of the poly(vinyl alcohol) (PVA) by the combination of cellulose nanocrystals (CNC) and poly (d,l-lactide-co-glycolide) (PLGA) nanoparticles (NPs) loaded with bovine serum albumin fluorescein isothiocynate conjugate (FITC-BSA). CNC were synthesized from microcrystalline cellulose by hydrolysis, while PLGA nanoparticles were produced by a double emulsion with subsequent solvent evaporation. Firstly, binary bio-nanocomposites with different CNC amounts were developed in order to select the right content of CNC. Next, ternary PVA/CNC/NPs bio-nanocomposites were developed. The addition of CNC increased the elongation properties without compromising the other mechanical responses. Thermal analysis underlined the nucleation effect of the synergic presence of cellulose and nanoparticles. Remarkably, bio-nanocomposite films are suitable to vehiculate biopolymeric nanoparticles to adult bone marrow mesenchymal stem cells successfully, thus representing a new tool for drug delivery strategies.