Cancer letters, 2014-01, Vol.342 (1), p.159-166
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Systematic combination screening reveals synergism between rapamycin and sunitinib against human lung cancer
- Ist Teil von
- Cancer letters, 2014-01, Vol.342 (1), p.159-166
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • We developed systematic binary screening platform for rapamycin-based cancer therapy. • Sunitinib displayed significant synergy with rapamycin in NSCLC cells. • Rapamycin and sunitinib possessed synergistic activity against mTOR signaling, proliferation and angiogenesis. • We established a mechanistic rationale for combinatorial use of rapalogs and sunitinib in the treatment of human NSCLC.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2013.08.046Titel-ID: cdi_proquest_miscellaneous_1459974798
- Format
- –
- Schlagworte
- Angiogenesis, Angiogenesis Inhibitors - pharmacology, Animals, Cancer therapies, Carcinoma, Non-Small-Cell Lung - blood supply, Carcinoma, Non-Small-Cell Lung - drug therapy, Cell cycle, Cell growth, Cell Line, Tumor - drug effects, Cell Proliferation - drug effects, Chick Embryo, Chorioallantoic Membrane - blood supply, Chorioallantoic Membrane - drug effects, Combination, Drug Screening Assays, Antitumor - methods, Drug Synergism, Drug therapy, G1 Phase Cell Cycle Checkpoints, Gene Expression - drug effects, Hematology, Oncology and Palliative Medicine, Human Umbilical Vein Endothelial Cells - drug effects, Human Umbilical Vein Endothelial Cells - physiology, Humans, Hypoxia-Inducible Factor 1, alpha Subunit - genetics, Hypoxia-Inducible Factor 1, alpha Subunit - metabolism, Indoles - pharmacology, Inhibitory Concentration 50, Lung cancer, Lung Neoplasms - blood supply, Lung Neoplasms - drug therapy, Non-small cell lung cancer, Phosphorylation, Protein Processing, Post-Translational - drug effects, Proto-Oncogene Proteins c-akt - metabolism, Pyrroles - pharmacology, Rapamycin, Rats, Rats, Sprague-Dawley, Rodents, Signal Transduction, Sirolimus - pharmacology, Sunitinib, Tissue Culture Techniques, TOR Serine-Threonine Kinases - metabolism, Vascular Endothelial Growth Factor A - secretion