UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 12 von 528
Datensatz exportieren als...
BibTeX
Interleukin-11 Increases Cell Motility and Up-Regulates Intercellular Adhesion Molecule-1 Expression in Human Chondrosarcoma Cells
Journal of cellular biochemistry, 2012-11, Vol.113 (11), p.3353-3362
Li, Te-Mao
Wu, Chi-Ming
Huang, Hsin-Chih
Chou, Pei-Chi
Fong, Yi-Chin
Tang, Chih-Hsin
2012
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Li, Te-Mao
Wu, Chi-Ming
Huang, Hsin-Chih
Chou, Pei-Chi
Fong, Yi-Chin
Tang, Chih-Hsin
Titel
Interleukin-11 Increases Cell Motility and Up-Regulates Intercellular Adhesion Molecule-1 Expression in Human Chondrosarcoma Cells
Ist Teil von
Journal of cellular biochemistry, 2012-11, Vol.113 (11), p.3353-3362
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Interleukin‐11 (IL‐11) was originally identified as the cytokine that could induce the proliferation of human cells. Recent studies have shown that IL‐11 plays a critical role in tumor growth, angiogenesis, and metastasis. Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. However, the effects of IL‐11 on human chondrosarcoma cells are largely unknown. Here, we found that IL‐11 increased the migration and expression of intercellular adhesion molecule‐1 (ICAM)‐1 in human chondrosarcoma cells. We also found that human chondrosarcoma tissues had significant expression of the IL‐11 which was higher than that in primary chondrocytes. The phosphatidylinositol 3‐kinase (PI3K), Akt, and NF‐κB pathways were activated by IL‐11 treatment, and the IL‐11‐induced expression of ICAM‐1 and migration activity were inhibited by the specific inhibitors and mutant forms of PI3K, Akt, and NF‐κB cascades. Taken together, our results indicate that IL‐11 enhanced the migration of the chondrosarcoma cells by increasing ICAM‐1 expression through the IL‐11Rα receptor, PI3K, Akt, and NF‐κB signal transduction pathway. J. Cell. Biochem. 113: 3353–3362, 2012. © 2012 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0730-2312
eISSN: 1097-4644
DOI: 10.1002/jcb.24211
Titel-ID: cdi_proquest_miscellaneous_1458536164
Format
–
Schlagworte
Bone Neoplasms - genetics
,
Bone Neoplasms - metabolism
,
Bone Neoplasms - pathology
,
Case-Control Studies
,
Cell Movement - drug effects
,
Chondrocytes - cytology
,
Chondrocytes - metabolism
,
CHONDROSARCOMA
,
Chondrosarcoma - genetics
,
Chondrosarcoma - metabolism
,
Chondrosarcoma - pathology
,
Enzyme Inhibitors - pharmacology
,
Humans
,
ICAM-1
,
IL-11
,
Intercellular Adhesion Molecule-1 - genetics
,
Intercellular Adhesion Molecule-1 - metabolism
,
Interleukin-11 - antagonists & inhibitors
,
Interleukin-11 - genetics
,
Interleukin-11 Receptor alpha Subunit - genetics
,
Interleukin-11 Receptor alpha Subunit - metabolism
,
MIGRATION
,
NF-kappa B - genetics
,
NF-kappa B - metabolism
,
Phosphatidylinositol 3-Kinase - genetics
,
Phosphatidylinositol 3-Kinase - metabolism
,
Proto-Oncogene Proteins c-akt - genetics
,
Proto-Oncogene Proteins c-akt - metabolism
,
RNA, Small Interfering - genetics
,
Signal Transduction - drug effects
,
Tumor Cells, Cultured
,
Up-Regulation - drug effects
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX