Details

Autor(en) / Beteiligte

• Luo, Xin
• Yao, Run-si
• Song, Hong
• Jiang, Xue-feng
• Lan, Jian-fa
• Shuai, Han-lin
• Wang, Xiao-yu
• Li, Rui-man
• Liu, Qiu-ying
• Wang, Yi-fei

Titel

Study on human umbilical cord mesenchymal stem cells transplantation in treatment of stress urinary incontinence in rats

Ist Teil von

• Chung-hua fu chʿan kʿo tsa chih, 2013-08, Vol.48 (8), p.579-583

Ort / Verlag

China

Erscheinungsjahr

2013

Quelle

Elektronische Zeitschriftenbibliothek - Freely accessible e-journals

Beschreibungen/Notizen

• To investigate the feasibility and effectiveness of human umbilical cord mesenchymal stem cells (HUCMSC) transplantation in the treatment of female stress urinary incontinence (SUI) in rats. The 14 female SD rats of SUI model were established by vaginal balloon dilation after birth and maintain this status for four hours bilateral ovariectomy were performed after two weeks and were routinely reared for two months, then 12 SUI rat model were made. Two months later, transfected with plasmid pEGFP-N1 of HUCMSC were injected into the region surrounding the urinary tract matched with saline injection as control group. To get genitourinary tissue after testing urodynamic indicators, and observe the pathological changes of the bladder, urethra and the surrounding tissue; fluorescent cell of the experimental groups specimens were observed by fluorescence microscope. The leak point pressure(LPP) was (23.8 ± 4.2) mm Hg(1 mm Hg = 0.133 kPa) of the SUI rats. Transplanting mesenchymal stem cells of SUI rats, the positive