Details

Autor(en) / Beteiligte

• Schieferstein, G.J.
• Littlefield, N.A.
• Gaylor, D.W.
• Sheldon, W.G.
• Burger, G.T.

Titel

Carcinogenesis of 4-aminobiphenyl in BALB/cStCrlfC3Hf/Nctr mice

Ist Teil von

• European journal of cancer & clinical oncology, 1985-01, Vol.21 (7), p.865-873

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

1985

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Male and female (840 each) BALB/cStCrlfC3Hf/Nctr mice were given 0, 7, 14, 28, 55, 110 and 220, and 0, 7, 19, 38, 75, 150 and 300 ppm, respectively, of 4-aminobiphenyl in their drinking water. Necropsies on killed animals were performed at 13, 26, 39, 52 and 96 weeks on dose. Dose-related neoplasms were angiosarcomas, bladder urothelial carcinomas and hepatocellular neoplasms. The non-neoplastic dose-related lesions were left atrial thrombosis, bladder urothelial hyperplasia, splenic hemosiderosis and splenic erythropoiesis. The incidences of bladder carcinoma and atrial thrombosis were higher in the males and the incidences of hepatocellular neoplasms and angiosarcomas were higher in the females.