Organic letters, 2013-11, Vol.15 (21), p.5488-5491
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p‑Smad3 from Ganoderma lucidum
- Ist Teil von
- Organic letters, 2013-11, Vol.15 (21), p.5488-5491
- Ort / Verlag
- United States: American Chemical Society
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- (+)-Lingzhiol and (−)-lingzhiol, a pair of rotary door-shaped meroterpenoidal enantiomers, were isolated from Ganoderma lucidum. Their structures were identified by spectroscopic methods and X-ray diffraction crystallography. Lingzhiol bears an unusual 5/5/6/6 ring system characteristic of sharing a C-3′–C-7′ axis. Biological evaluation showed that (+)-lingzhiol or (−)-lingzhiol could selectively inhibit the phosphorylation of Smad3 in TGF-β1-induced rat renal proximal tubular cells and activate Nrf2/Keap1 in mesangial cells under diabetic conditions.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1523-7060eISSN: 1523-7052DOI: 10.1021/ol4026364Titel-ID: cdi_proquest_miscellaneous_1449266746
- Format
- –
- Schlagworte
- Animals, Mesangial Cells - chemistry, Mesangial Cells - metabolism, Molecular Structure, Phosphorylation, Rats, Reishi - chemistry, Reishi - metabolism, Smad3 Protein - antagonists & inhibitors, Smad3 Protein - chemistry, Smad3 Protein - metabolism, Terpenes - chemistry, Transforming Growth Factor beta1 - chemistry, Transforming Growth Factor beta1 - metabolism, X-Ray Diffraction