Details

Autor(en) / Beteiligte

• Flossbach, Lucia
• Holzmann, Karlheinz
• Mattfeldt, Torsten
• Buck, Michaela
• Lanz, Karin
• Held, Michael
• Möller, Peter
• Barth, Thomas F.E.

Titel

High‐resolution genomic profiling reveals clonal evolution and competition in gastrointestinal marginal zone B‐cell lymphoma and its large cell variant

Ist Teil von

• International journal of cancer, 2013-02, Vol.132 (3), p.E116-E127

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Wiley(RISS)

Beschreibungen/Notizen

• We studied marginal zone B‐cell lymphomas of the gastrointestinal tract including seven small cell lymphomas, eight large cell areas of composite lymphomas and 13 large cell variants using SNP array profiling. We found an increase of genomic complexity with lymphoma progression from small to large cytology, and identified gains of prominent (proto) oncogenes such as REL, BCL11A, ETS1, PTPN1, PTEN and KRAS which were found exclusively in the large cell variants. Copy numbers of ADAM3A, SCAPER and SIRPB1 were varying between the three different modes of presentation, hence suggestive for aberrations associated with progression from small to large cell lymphoma. The number of aberrations was slightly higher in the large cell part of composite lymphomas than in large cell lymphomas, suggesting that clonal selection takes place and that composite lymphomas are in a transition state. To further investigate this, we comparatively analyzed samples of two morphologically different regions of the same small cell tumor with a BIRC3‐MALT1 translocation, as well as material acquired at two different time points from one composite lymphoma. We found genomic heterogeneity in both cases, supporting the theory of competing subclones in the evolution and progression of extranodal marginal zone B‐cell lymphoma. What's new? Evidence that certain small cell and large cell lymphomas have similar gene expression profiles has raised intriguing questions about the genetics of lymphoma. Here, profiling of genetic variations in gastrointestinal lymphomas revealed that large cell lymphomas may arise from small cell lymphomas, with composite cancers of clonally related small and large cells representing a transition state. The findings support the idea that gastrointestinal large cell lymphomas are a distinct subtype of diffuse large B‐cell lymphoma.