Details

Autor(en) / Beteiligte

• Lindberg, F
• Normark, S

Titel

Contribution of chromosomal beta -lactamases to beta -lactam resistance in enterobacteria

Erscheinungsjahr

1986

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The two most important factors determining the level of beta -lectam resistance to novel cephalosporins in gram-negative enterobacteria are the chromosomal class C beta -lactamases, which have high affinity for these compounds, and the outer membrane permeability barrier. Wild-type strains carry a chromosomal gene, ampC , encoding class C beta -lactamases. Expression from this gene is normally low, but it can in some species be induced by beta -lactam agents and related compounds. The current knowledge on he molecular mechanism governing both inducible and constitutive beta -lactamase synthesis is reviewed.