Details

Autor(en) / Beteiligte

• Lv, Jicheng, MD
• Shi, Sufang, MD
• Xu, Damin, MD
• Zhang, Hong, MD, PhD
• Troyanov, Stéphan, MD
• Cattran, Daniel C., MD
• Wang, Haiyan, MD

Titel

Evaluation of the Oxford Classification of IgA Nephropathy: A Systematic Review and Meta-analysis

Ist Teil von

• American journal of kidney diseases, 2013-11, Vol.62 (5), p.891-899

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background The Oxford Classification of the pathology of immunoglobulin A (IgA) nephropathy, developed in 2009, is highly predictive of renal prognosis. It has been validated in different populations, but the results remain inconsistent. Study Design Systematic review and meta-analysis. Setting & Population Patients with biopsy-proven primary IgA nephropathy. Selection Criteria for Studies Studies assessing the Oxford Classification of IgA nephropathy published between January 2009 and December 2012 were included following systematic searching of the MEDLINE and EMBASE databases. Predictor 4 pathologic lesions of the Oxford Classification: mesangial hypercellularity (M), endocapillary hypercellularity (E), segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T). Outcome Kidney failure defined as doubled serum creatinine level, 50% decline in estimated glomerular filtration rate, or end-stage kidney disease. Results 16 retrospective cohort studies with 3,893 patients and 570 kidney failure events were included. In a multivariate model, HRs for kidney failure were 0.6 (95% CI, 0.5-0.8; P < 0.001), 1.8 (95% CI, 1.4-2.4; P < 0.001), and 3.2 (95% CI, 1.8-5.6; P < 0.001) for scores of M0 (mesangial hypercellularity score ≤0.5), S1 (presence of segmental glomerulosclerosis), and T1/2 (>25% tubular atrophy/interstitial fibrosis), respectively, without evidence of heterogeneity. Pooled results showed that E lesions were not associated with kidney failure (HR, 1.4; 95% CI, 0.9-2.0; P = 0.1), with evidence of heterogeneity ( I2 = 54.1%; P = 0.01). Crescent (C) lesions were associated with kidney failure (HR, 2.3; 95% CI, 1.6-3.4; P < 0.001), with no evidence of heterogeneity ( I2 = 14.7%; P = 0.3). Limitations All studies were retrospective. This was not an individual-patient-data meta-analysis. Conclusions This study suggests that M, S, T, and C lesions, but not E lesions, are associated strongly with progression to kidney failure and thus should be included in the Oxford Classification system.