Details

Autor(en) / Beteiligte

• Platonova, T. A.
• Pridvorova, S. M.
• Zherdev, A. V.
• Vasilevskaya, L. S.
• Arianova, E. A.
• Gmoshinski, I. V.
• Khotimchenko, S. A.
• Dzantiev, B. B.
• Popov, V. O.
• Tutelyan, V. A.

Titel

Identification of Silver Nanoparticles in the Small Intestinal Mucosa, Liver, and Spleen of Rats by Transmission Electron Microscopy

Ist Teil von

• Bulletin of experimental biology and medicine, 2013-06, Vol.155 (2), p.236-241

Ort / Verlag

Boston: Springer US

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• The effects of water-dispersed Ag nanoparticles on the small intestinal mucosa, liver, and spleen of rats were studied by transmission electron microscopy. Acute experiments demonstrated penetration of Ag nanoparticles injected into the isolated intestinal loop into the intestinal mucosa, liver, and splenic tissues. Ultrastructural changes (lobed nucleus, megamitochondria) were found in the studied organs. These data indicated that injection of waterdispersed Ag nanoparticles into the gastrointestinal tract was followed by their penetration through the epithelium of the small intestinal mucosa into other organs, e.g. into the liver and spleen. This fact is essential for evaluation of potential risks of the nanoparticle effects on human health and environment.