Angewandte Chemie International Edition, 2013-10, Vol.52 (42), p.11021-11024
International ed. in English, 2013
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Opsin, a Structural Model for Olfactory Receptors?
- Ist Teil von
- Angewandte Chemie International Edition, 2013-10, Vol.52 (42), p.11021-11024
- Auflage
- International ed. in English
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Receptor–ligand interaction: Olfactory receptors (ORs) are G‐protein‐coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand‐binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant–receptor recognition.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1433-7851eISSN: 1521-3773DOI: 10.1002/anie.201302374Titel-ID: cdi_proquest_miscellaneous_1443419999
- Format
- –
- Schlagworte
- GPCR, homology modeling, Humans, Models, Molecular, olfactory receptor, Olfactory Receptor Neurons - chemistry, Olfactory Receptor Neurons - metabolism, Opsins - chemistry, Opsins - metabolism, protein structures, receptors, Receptors, G-Protein-Coupled - chemistry, Receptors, G-Protein-Coupled - metabolism