Details

Autor(en) / Beteiligte

• Chaineau, Mathilde
• Ioannou, Maria S.
• McPherson, Peter S.

Titel

Rab35: GEFs, GAPs and Effectors

Ist Teil von

• Traffic (Copenhagen, Denmark), 2013-11, Vol.14 (11), p.1109-1117

Ort / Verlag

Former Munksgaard: John Wiley & Sons A/S

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Rabs are the largest family of small GTPases and are master regulators of membrane trafficking. Following activation by guanine‐nucleotide exchange factors (GEFs), each Rab binds a specific set of effector proteins that mediate the various downstream functions of that Rab. Then, with the help of GTPase‐activating proteins, the Rab converts GTP to GDP, terminating its function. There are over 60 Rabs in humans and only a subset has been analyzed in any detail. Recently, Rab35 has emerged as a key regulator of cargo recycling at endosomes, with an additional role in regulation of the actin cytoskeleton. Here, we will focus on the regulation of Rab35 activity by the connecdenn/DENND1 family of GEFs and the TBC1D10/EPI64 family of GTPase‐activating proteins. We will describe how analysis of these proteins, as well as a plethora of Rab35 effectors has provided insights into Rab35 function. Finally, we will describe how Rab35 provides a novel link between the Rab and Arf family of GTPases with implications for tumor formation and invasiveness. The small GTPases Rab35 has emerged as a key regulator of endosomal membrane trafficking and actin cytoskeletal dynamics. Here we describe the GEFs that activate Rab35, the GAPs that inactivate Rab35, and the effectors that mediate its diverse biological functions.