Details

Autor(en) / Beteiligte

• Markus, Marcello Ricardo Paulista
• Stritzke, Jan
• Baumeister, Sebastian Edgar
• Siewert, Ulrike
• Baulmann, Johannes
• Hannemann, Anke
• Schipf, Sabine
• Meisinger, Christa
• Dörr, Marcus
• Felix, Stephan Burkhart
• Keil, Ulrich
• Völzke, Henry
• Hense, Hans-Werner
• Schunkert, Heribert

Titel

Effects of smoking on arterial distensibility, central aortic pressures and left ventricular mass

Ist Teil von

• International journal of cardiology, 2013-10, Vol.168 (3), p.2593-2601

Ort / Verlag

Shannon: Elsevier Ireland Ltd

Erscheinungsjahr

2013

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Abstract Background The effects of smoking on central aortic pressures and the age-related increase in left ventricular mass (LVM) are largely unknown. We studied the relationship between smoking, arterial distensibility, central aortic pressures and left ventricular mass in two population-based studies. Methods Data was obtained from two German population-based studies (KORA and SHIP, participants' ages 25–84 years). We identified 114 normotensive current smokers and 185 normotensive all-time non-smokers in KORA as well as 400 and 588 such individuals in SHIP. Echocardiographic LVM was obtained at baseline (T0) and follow-up after ten years (T1) in KORA and at follow-up (T1) in SHIP. Additionally, pulse-wave analysis-based central aortic pressure and augmentation index (AIx) were measured at T1 in KORA. Results Cross-sectional analysis, using KORA T0 and SHIP T1, revealed in both studies a higher covariate-adjusted LVM and left ventricular mass index (LVMI) in smokers as compared with non-smokers. Moreover, in the KORA T1 examination, the smokers demonstrated a more pronounced increase, relative to baseline, of LVM (+ 13.5%) and LVMI (+ 13.4%) compared to non-smokers (+ 8.59% and + 8.65%; p = 0.036 and 0.042, respectively). Additionally, at KORA T1 smokers had a higher central systolic blood pressure and higher AIx than non-smokers (p = 0.012 and p = 0.001, respectively). Conclusions The difference in central aortic pressure due to enhanced and more prolonged wave reflection may explain our finding of a further pronounced increase in left ventricular wall thickness and mass over time in smokers.