Hepatobiliary & pancreatic diseases international, 2013-10, Vol.12 (5), p.465-472
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Prevention of recurrent hepatitis B infection after liver transplantation
- Ist Teil von
- Hepatobiliary & pancreatic diseases international, 2013-10, Vol.12 (5), p.465-472
- Ort / Verlag
- Singapore: Elsevier B.V
- Erscheinungsjahr
- 2013
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- BACKGROUND:Recurrence of hepatitis B virus(HBV) infection after liver transplantation can lead to graft loss and a reduction in long-term survival.The purpose of this review is to summarize the current therapeutic options for preventing HBV recurrence in liver transplant recipients.DATA SOURCES:Up to January 2013,studies that were published in MEDLINE and EMBASE on prevention of HBV recurrence after liver transplantation were reviewed.RESULTS:There have been remarkable advancements in the past two decades on the prevention of HBV recurrence after liver transplantation,from the discovery of hepatitis B immune globulin(HBIG) and lamivudine monotherapy to the combination therapy using HBIG and lamivudine.With the development of newer and stronger antiviral agents,the need for life-long HBIG is doubtful.With their low resistance profile,oral antiviral prophylaxis using these new agents alone is sufficient and is associated with excellent outcome.CONCLUSIONS:Restoration of host HBV immunity with adoptive immunity transfer and vaccination may represent the ultimate strategy to withdraw prophylactic treatment and to achieve a drug free regimen against HBV recurrence after liver transplantation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1499-3872DOI: 10.1016/S1499-3872(13)60074-0Titel-ID: cdi_proquest_miscellaneous_1443396063
- Format
- –
- Schlagworte
- Adaptive Immunity, Administration, Oral, adoptive, adoptive immunity transfer, Adoptive Transfer, antiviral, Antiviral Agents - administration & dosage, Antiviral Agents - adverse effects, Antiviral Agents - therapeutic use, antiviral therapy, Drug Administration Schedule, Drug Resistance, Viral, Endocrinology & Metabolism, Gastroenterology and Hepatology, globulin, HBV, HBV vaccination, hepatitis, hepatitis B, Hepatitis B - diagnosis, Hepatitis B - immunology, Hepatitis B - prevention & control, hepatitis B immune globulin, Hepatitis B Vaccines - therapeutic use, Hepatitis B virus - drug effects, Hepatitis B virus - growth & development, Hepatitis B virus - immunology, Humans, immune, immunity, Immunoglobulins - therapeutic use, Lamivudine - therapeutic use, liver, liver transplantation, Liver Transplantation - adverse effects, Secondary Prevention, therapy, transfer, transplantation, Treatment Outcome, vaccination, Virus Activation - drug effects