Details

Autor(en) / Beteiligte

• Tisset, Hélène
• Kamar, Nassim
• Faugeron, Isabelle
• Roy, Pascal
• Pouteil-Noble, Claire
• Klein, Marc
• Mourad, Georges
• Drui, Delphine
• Do Cao, Christine
• Leenhardt, Laurence
• Allix, Ingrid
• Bonichon, Françoise
• Morelon, Emmanuel
• Leboulleux, Sophie
• Kelly, Antony
• Niccoli, Patricia
• Toubert, Marie-Elisabeth
• Frimat, Luc
• Vantyghem, Marie-Christine
• Bournaud, Claire
• Schlumberger, Martin
• Borson-Chazot, Françoise
• the TUTHYREF network

Titel

Is Thyroid Cancer Recurrence Risk Increased After Transplantation?

Ist Teil von

• The journal of clinical endocrinology and metabolism, 2013-10, Vol.98 (10), p.3981-3988

Ort / Verlag

Bethesda, MD: Endocrine Society

Erscheinungsjahr

2013

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Context: An increased cancer mortality is reported in transplanted patients. Objective: This multicentric study aimed to investigate the rate of thyroid cancer recurrence after transplantation. Results: Sixty-eight patients (35 male/33 female) with a history of both thyroid cancer and organ transplantation were recruited via two nationwide French networks. Histological analysis identified 58 papillary (88%), 5 follicular (7.5%), and 3 poorly differentiated cancer cases (4.5 %). Thirty-one patients (52%) presented high recurrence risk tumors. In the 36 patients with thyroid cancer diagnosed after transplantation, the 5-year disease-free survival (DFS) was 74.7% (SE: 7.3%). One patient died after progression of a poorly differentiated cancer. Persistent disease was observed in six high-risk patients. One of them underwent a second transplantation and disease remained stable after 5 years of follow-up. Thyroid cancer had been diagnosed before transplantation in 32 patients. One patient with cystic fibrosis and thyroid lung metastases at the time of lung transplantation underwent a 4-year remission. For the 31 patients in remission at the time of transplantation, the 5-year DFS was 93.1% (SE: 4.8%). Two patients with local recurrence presented subsequent remission. For the entire study population, the 5-year and 9-year DFS were 81.9% (SE: 5.5%) and 75.6% (SE: 7.9%), respectively. Recurrence or persistent disease occurred in patients with high-risk tumors. Conclusions: The prognosis of thyroid cancer does not seem to be altered by transplantation. This suggests that a history of thyroid cancer should not be considered a contraindication.