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HPV persistence and its oncogenic role in prostate tumors
Journal of medical virology, 2012-10, Vol.84 (10), p.1636-1645
Tachezy, Ruth
Hrbacek, Jan
Heracek, Jiri
Salakova, Martina
Smahelova, Jana
Ludvikova, Viera
Svec, Alexandr
Urban, Michael
Hamsikova, Eva
2012
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Tachezy, Ruth
Hrbacek, Jan
Heracek, Jiri
Salakova, Martina
Smahelova, Jana
Ludvikova, Viera
Svec, Alexandr
Urban, Michael
Hamsikova, Eva
Titel
HPV persistence and its oncogenic role in prostate tumors
Ist Teil von
Journal of medical virology, 2012-10, Vol.84 (10), p.1636-1645
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
HPV has carcinogenic effects at several anatomical sites in women and men. Whether the presence of HPV in the genitourinary tract of men is associated with a higher prostate cancer risk has been a matter of research for a long‐time and the results are still not fully conclusive. Similarly, the question of the reservoir of HPV infection in men is not clearly resolved. HPV DNA presence and types were evaluated by means of polymerase chain reaction in the tissue of 146 patients with benign prostate hyperplasia and prostate cancer. HPV‐specific antibodies were analyzed by enzyme‐linked immunosorbent assay in the sera of all patients and 172 controls. In addition, 256 biopsies taken from non‐tumorous tissues were analyzed. No statistically significant differences were observed in HPV DNA prevalence between patients with benign prostate hyperplasia (2%) and patients with prostatic cancer (2%; P = 1.000). The seropositivity rates did not differ significantly between groups of subjects except for antibodies against HPV 6 VLPs which were found more often in prostate cancer patients (adjusted P = 0.018). Similarly, no difference in the seroprevalence rates for HPV 16 E6 and/or E7 oncoproteins between groups of patients and healthy controls was detected. The overall HPV prevalence in 256 healthy tissue samples was 4%. The results indicate that HPV infection is not associated with prostate oncogenesis in men. However, they imply that multiple tissues of the male genitourinary tract may be important reservoirs for the transmission of some HPV types. J. Med. Virol. 84:1636–1645, 2012. © 2012 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0146-6615
eISSN: 1096-9071
DOI: 10.1002/jmv.23367
Titel-ID: cdi_proquest_miscellaneous_1443378233
Format
–
Schlagworte
Aged
,
Aged, 80 and over
,
Antibodies
,
Antibodies, Viral - blood
,
Biological and medical sciences
,
Biopsy
,
Disease transmission
,
DNA
,
DNA, Viral - isolation & purification
,
Enzyme-Linked Immunosorbent Assay
,
Fundamental and applied biological sciences. Psychology
,
Genotype
,
Human papillomavirus
,
Human viral diseases
,
Humans
,
Infectious diseases
,
Male
,
Medical sciences
,
men
,
Microbiology
,
Middle Aged
,
Miscellaneous
,
Oncology
,
Papillomaviridae - classification
,
Papillomaviridae - genetics
,
Papillomaviridae - isolation & purification
,
Papillomaviridae - pathogenicity
,
Papillomavirus Infections - complications
,
Papillomavirus Infections - virology
,
PCR
,
Polymerase Chain Reaction
,
Prevalence
,
Prostate cancer
,
Prostatic Neoplasms - epidemiology
,
Prostatic Neoplasms - virology
,
reservoir
,
Tumors
,
Viral diseases
,
Virology
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