Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Identification of ABC Transporter Genes in Gonad Tissue of Two Mediterranean Sea Urchin Species: Black, Arbacia lixula L., and Rocky, Paracentrotus lividus L
Ist Teil von
Bulletin of environmental contamination and toxicology, 2013-10, Vol.91 (4), p.415-419
Ort / Verlag
New York: Springer US
Erscheinungsjahr
2013
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Multixenobiotic resistance (MXR) represents an important cellular detoxification mechanism in aquatic organisms as it provides them robustness toward natural and man-made contaminants. Several ABC transporters have major roles in the MXR phenotype – P-gp/ABCB1, MRP1–3/ABCC1–3 and BCRP/ABCG2. In this study, we identified the presence of ABC transporters involved in the MXR mechanism of
Arbacia lixula
and
Paracentrotus lividus
.
Al
ABCB1/P-gp,
Al
ABCC3/MRP3,
Al
ABCC9/SUR-like and
Al
ABCG-like transcripts were identified in
A. lixula
; and
Pl
ABCC1/P-gp,
Pl
ABCC3/MRP3,
Pl
ABCC5/MRP5, and
Pl
ABCC9/SUR-like transcripts in
P. lividus
. For each of the new partial sequences, we performed detailed phylogenetic and identity analysis as a first step toward full characterization and understanding of the ecotoxicological role of these ABC transporters.