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IOTA simple rules for discriminating between benign and malignant adnexal masses: prospective external validation
Ultrasound in obstetrics & gynecology, 2013-10, Vol.42 (4), p.467-471
Alcázar, J. L.
Pascual, M. Á.
Olartecoechea, B.
Graupera, B.
Aubá, M.
Ajossa, S.
Hereter, L.
Julve, R.
Gastón, B.
Peddes, C.
Sedda, F.
Piras, A.
Saba, L.
Guerriero, S.
2013
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Alcázar, J. L.
Pascual, M. Á.
Olartecoechea, B.
Graupera, B.
Aubá, M.
Ajossa, S.
Hereter, L.
Julve, R.
Gastón, B.
Peddes, C.
Sedda, F.
Piras, A.
Saba, L.
Guerriero, S.
Titel
IOTA simple rules for discriminating between benign and malignant adnexal masses: prospective external validation
Ist Teil von
Ultrasound in obstetrics & gynecology, 2013-10, Vol.42 (4), p.467-471
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2013
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
ABSTRACT Objective To determine the diagnostic performance of International Ovarian Tumor Analysis (IOTA) ‘simple’ rules for discriminating between benign and malignant adnexal masses. Methods A prospective study was performed between January 2011 and June 2012. Eligible patients were women diagnosed with a persistent adnexal mass who presented to the participating centers. Four trainees evaluated the adnexal mass by transvaginal ultrasound under the supervision of an expert examiner. The trainee analyzed the mass according to IOTA simple rules and provided a diagnosis of benign, malignant or inconclusive. All women included in the study underwent surgery and tumor removal in the center of recruitment. Diagnostic performance was assessed by calculating sensitivity, specificity and positive (LR+) and negative (LR–) likelihood ratios. Results A total of 340 women were included (mean patient age, 42.1 (range, 13–79) years). Of the tumors, 55 (16.2%) were malignant and 285 (83.8%) were benign. The IOTA simple rules could be applied in 270 (79.4%) cases. In these cases, sensitivity was 87.9% (95% CI, 72.4–95.2), specificity 97.5% (95% CI, 94.6–98.8), LR+ 34.7 (95% CI, 15.6–77.3) and LR– 0.12 (95% CI, 0.05–0.31). Conclusions Application of the IOTA simple rules yielded acceptable results in terms of specificity in the hands of non‐expert examiners. However, with non‐expert examiners there was a 12% false‐negative rate, which is relatively high. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0960-7692
eISSN: 1469-0705
DOI: 10.1002/uog.12485
Titel-ID: cdi_proquest_miscellaneous_1443374405
Format
–
Schlagworte
Adnexal Diseases - diagnostic imaging
,
Adnexal Diseases - pathology
,
adnexal mass
,
Adolescent
,
Adult
,
Aged
,
diagnosis
,
Diagnosis, Differential
,
Early Detection of Cancer
,
Female
,
Humans
,
Menopause
,
Middle Aged
,
Neoplasm Staging
,
Pelvic Neoplasms - diagnostic imaging
,
Pelvic Neoplasms - pathology
,
Prospective Studies
,
sensitivity
,
specificity
,
Ultrasonography
,
ultrasound
,
Young Adult
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