Details

Autor(en) / Beteiligte

• Yang, Shan
• Adhikari, Sanjay
• Dobbala, Manoj
• Adusumilli, Sasidhar
• Rowley, Joseph D.
• Ganikhanov, Feruz
• Zhang, Lingquin
• Marrs, Glen
• Wysolmerski, Robert
• Spirou, George

Titel

Multi-color ultrafast laser platform for nonlinear optical imaging based on independently tunable optical parametric oscillators

Ist Teil von

• Applied physics. B, Lasers and optics, 2013-06, Vol.111 (4), p.617-625

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2013

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• We report on design of a multi-color laser set up that allows for high spectral, time and spatial resolution imaging based on second- and third-order optical nonlinearities in soft condensed matter. Two femtosecond optical parametric oscillators (OPOs) are pumped simultaneously to provide intrinsically synchronized pulses at more than a dozen tunable colors across visible and infrared wavelengths. We demonstrate the use of independently tunable OPOs in a variety of imaging modalities. In one useful application, we explore brain tissue in a two-photon absorption fluorescence imaging experiment with near infrared optical pulses (λ ~ 1,070 nm). We also demonstrate second and sum-frequency generation microscopies in different tissues. Results from application of time-resolved, three-color coherent anti-stokes Raman scattering in tissue are presented to demonstrate feasibility of quantitative spectroscopic imaging.