Details

Autor(en) / Beteiligte

• Yilmaz, M
• Chemaly, R F
• Han, X Y
• Thall, P F
• Fox, P S
• Tarrand, J J
• De Lima, M J
• Hosing, C M
• Popat, U R
• Shpall, E
• Champlin, R E
• Qazilbash, M H

Titel

Adenoviral infections in adult allogeneic hematopoietic SCT recipients: a single center experience

Ist Teil von

• Bone marrow transplantation (Basingstoke), 2013-09, Vol.48 (9), p.1218-1223

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Disseminated adenoviral infection (AI) is associated with profound immunosuppression and poor outcome after allogeneic hematopoietic SCT (allo-HSCT). A better understanding of AI in allo-HSCT recipients can serve as a basis to develop more effective management strategies. We evaluated all adult patients who received allo-HSCT at MD Anderson Cancer Center between 1999 and 2008. Among the 2879 allo-HSCT patients, 73 (2.5%) were diagnosed with AI. Enteritis (26%) and pneumonia (24%) were the most common clinical manifestations; pneumonia was the most common cause of adenovirus-associated death. A multivariable Bayesian logistic regression showed that when the joint effects of all covariates were accounted for, cord blood transplant, absolute lymphocyte count (ALC) ⩽200/mm 3 and male gender were associated with a higher probability of disseminated AI. The OS was significantly worse for patients with AI that was disseminated rather than localized (median of 5 months vs median of 28 months, P <0.001) and for patients with ALC ⩽200/mm 3 ( P <0.001). Disseminated AI, in patients who received allo-HSCT, is a significant cause of morbidity and mortality. Strategies for early diagnosis and intervention are essential, especially for high-risk patients.