UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 11 von 390
Datensatz exportieren als...
BibTeX
RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary
The Journal of pathology, 2013-02, Vol.229 (3), p.469-476
Ryland, Georgina L
Hunter, Sally M
Doyle, Maria A
Rowley, Simone M
Christie, Michael
Allan, Prue E
Bowtell, David DL
Gorringe, Kylie L
Campbell, Ian G
2013
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Ryland, Georgina L
Hunter, Sally M
Doyle, Maria A
Rowley, Simone M
Christie, Michael
Allan, Prue E
Bowtell, David DL
Gorringe, Kylie L
Campbell, Ian G
Titel
RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary
Ist Teil von
The Journal of pathology, 2013-02, Vol.229 (3), p.469-476
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2013
Quelle
MEDLINE
Beschreibungen/Notizen
Mucinous carcinomas represent a distinct morphological subtype which can arise from several organ sites, including the ovary, and their genetic characteristics are largely under‐described. Exome sequencing of 12 primary mucinous ovarian tumours identified RNF43 as the most frequently somatically mutated novel gene, secondary to KRAS and mutated at a frequency equal to that of TP53 and BRAF. Further screening of RNF43 in a larger cohort of ovarian tumours identified additional mutations, with a total frequency of 2/22 (9%) in mucinous ovarian borderline tumours and 6/29 (21%) in mucinous ovarian carcinomas. Seven mutations were predicted to truncate the protein and one missense mutation was predicted to be deleterious by in silico analysis. Six tumours had allelic imbalance at the RNF43 locus, with loss of the wild‐type allele. The mutation spectrum strongly suggests that RNF43 is an important tumour suppressor gene in mucinous ovarian tumours, similar to its reported role in mucinous pancreatic precancerous cysts. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417
eISSN: 1096-9896
DOI: 10.1002/path.4134
Titel-ID: cdi_proquest_miscellaneous_1439227951
Format
–
Schlagworte
Adenocarcinoma, Mucinous - genetics
,
Adenocarcinoma, Mucinous - pathology
,
Computer Simulation
,
Cystadenoma, Mucinous - genetics
,
Cystadenoma, Mucinous - pathology
,
Cysts
,
DNA Mutational Analysis
,
DNA sequencing
,
DNA, Neoplasm - analysis
,
DNA-Binding Proteins - genetics
,
DNA-Binding Proteins - metabolism
,
Exome - genetics
,
Female
,
Genes, Tumor Suppressor - physiology
,
Humans
,
Models, Molecular
,
mucinous ovarian cancer
,
Mutation
,
Oncogene Proteins - genetics
,
Oncogene Proteins - metabolism
,
Ovarian Neoplasms - genetics
,
Ovarian Neoplasms - pathology
,
RNF43
,
Sequence Analysis, DNA
,
somatic mutation
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX