Details

Autor(en) / Beteiligte

• Ryoo, Inseon
• Choi, Seung Hong
• Kim, Ji-Hoon
• Sohn, Chul-Ho
• Kim, Soo Chin
• Shin, Hwa Seon
• Yeom, Jeong A
• Jung, Seung Chai
• Lee, A Leum
• Yun, Tae Jin

Titel

Cerebral Blood Volume Calculated by Dynamic Susceptibility Contrast-Enhanced Perfusion MR Imaging: Preliminary Correlation Study with Glioblastoma Genetic Profiles. e71704

Ist Teil von

• PloS one, 2013-08, Vol.8 (8)

Erscheinungsjahr

2013

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Purpose To evaluate the usefulness of dynamic susceptibility contrast (DSC) enhanced perfusion MR imaging in predicting major genetic alterations in glioblastomas. Materials and Methods Twenty-five patients (M:F = 13:12, mean age: 52.1 plus or minus 15.2 years) with pathologically proven glioblastoma who underwent DSC MR imaging before surgery were included. On DSC MR imaging, the normalized relative tumor blood volume (nTBV) of the enhancing solid portion of each tumor was calculated by using dedicated software (Nordic TumorEX, NordicNeuroLab, Bergen, Norway) that enabled semi-automatic segmentation for each tumor. Five major glioblastoma genetic alterations (epidermal growth factor receptor (EGFR), phosphatase and tensin homologue (PTEN), Ki-67, O6-methylguanine-DNA methyltransferase (MGMT) and p53) were confirmed by immunohistochemistry and analyzed for correlation with the nTBV of each tumor. Statistical analysis was performed using the unpaired Student t test, ROC (receiver operating characteristic) curve analysis and Pearson correlation analysis. Results The nTBVs of the MGMT methylation-negative group (mean 9.5 plus or minus 7.5) were significantly higher than those of the MGMT methylation-positive group (mean 5.4 plus or minus 1.8) (p = .046). In the analysis of EGFR expression-positive group, the nTBVs of the subgroup with loss of PTEN gene expression (mean: 10.3 plus or minus 8.1) were also significantly higher than those of the subgroup without loss of PTEN gene expression (mean: 5.6 plus or minus 2.3) (p = .046). Ki-67 labeling index indicated significant positive correlation with the nTBV of the tumor (p = .01). Conclusion We found that glioblastomas with aggressive genetic alterations tended to have a high nTBV in the present study. Thus, we believe that DSC-enhanced perfusion MR imaging could be helpful in predicting genetic alterations that are crucial in predicting the prognosis of and selecting tailored treatment for glioblastoma patients.