Details

Autor(en) / Beteiligte

• Rakic, Mia
• Lekovic, Vojislav
• Nikolic-Jakoba, Natasa
• Vojvodic, Danilo
• Petkovic-Curcin, Aleksandra
• Sanz, Mariano

Titel

Bone loss biomarkers associated with peri-implantitis. A cross-sectional study

Ist Teil von

• Clinical oral implants research, 2013-10, Vol.24 (10), p.1110-1116

Ort / Verlag

Denmark: Blackwell Publishing Ltd

Erscheinungsjahr

2013

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Aim To investigate the levels of biomarkers associated with osteoclastogenesis in patients suffering peri‐implantitis and to compare them with levels in healthy peri‐implant sites and severe chronic periodontitis. Material and methods Peri‐implant/gingival crevicular fluid samples and clinical parameters including: bleeding on probing, modified Plaque Index (PlI), pocket depth and clinical attachment level were collected from 70 patients (23 with peri‐implantitis, 25 with healthy peri‐implant tissues and 22 with severe chronic periodontitis). The concentrations of sRANKL, RANK and OPG were evaluated using enzyme‐linked immunosorbent assays; they were compared between the groups and correlated with the clinical findings. Results sRANKL (P = 0.01), RANK (P = 0.01) and OPG (P = 0.03) concentrations were significantly higher in peri‐implantitis sites when compared to those in healthy implant sites, although differences in the sRANKL/OPG ratio were not statistically significant. In these sites all three markers were significantly correlated with the clinical parameters, with exception of OPG/PI correlation that remained insignificant (P = 0.121). When comparing peri‐implantitis and periodontitis findings, RANK was significantly higher in peri‐implantitis sites whereas, sRANKL (P = 0.03) and sRANKL/OPG ratio (P = 0.004) were significantly higher in periodontitis sites. Among periodontitis and healthy implant sites the same differences have been observed for both sRANKL (P = 0.000) and sRANKL/OPG ratio (P = 0.000), furthermore RANK was higher in periodontitis sites as well (P = 0.010). Conclusion The findings of this preliminary study on a relatively small sample size suggest that the PICF levels of biomarkers sRANKL, RANK, and OPG are associated with peri‐implant tissue destruction and the pattern of these biomarkers differed when compared to periodontitis.